TISSUE ENGINEERING

Telea Biotech was founded by Telea Electronic Engineering for QMR applications in tissue engineering.

Tissue Engineering is the field of science that encloses the most diverse disciplines such as Medicine, Biology and Engineering, and that affects the regeneration of portions of biological tissue or even whole organs through the engineering of new biomaterials. These biomaterials are called scaffolds and serve as support for the growth of new fully functional tissues. They allow to overcome the limitations imposed by the need to find organs from donors which, requires time, is very expensive and presents big problems of rejection. These also involve, on the one hand, a reduction in the quality and in the expectancy of patient’s life, and on the other an increase in health care costs.

The biomaterials are divided into two groups: synthetic and natural. The first are created in laboratory and they try to faithfully recreate the structure and characteristics of natural tissue. They can have three-dimensional structures that allow cells to find a favourable environment for adhesion and growth as they simulate the effect of a niche or a structure in which the stem cells find shelter and nutrients needed for its maintenance. Natural scaffolds have instead, already embedded, all the chemical-physical characteristics of the tissues that need to be replaced and they maintain unchanged the characteristics of the extracellular matrix protein structures; therefore the cells in contact with them can find the right signals for differentiation in the direction of its natural tissue, exactly as it happens in the human body.

Telea Biotech aims to unify the positive characteristics of both types into one naturally derived scaffold. All this thanks to QMR technology, which allows to produce a series of micro holes within the tissue matrix of animal origin and which, consequently, allows to realize a three-dimensional structure, ideal for the growth and proliferation of stem cells (but which can be perfectly suitable also to other biological factors such as platelet lysates or other substances in order to improve its effectiveness, as has already been amply demonstrated in the literature and from experiments made for many years by Telea Biotech with the University of Padua). It also maintains all the physical and chemical properties of the original structure. Therefore, the seeded cells can immediately recognize the environment to which they attach and can differentiate in the same tissue, thus going to repopulate the entire scaffold that slowly will be totally replaced with a new fully functional tissue and thereby completing its regeneration.

The unique and exclusive treatment patented by Telea Biotech may be achieved only by using QMR technology and can be applied to a great variety of different soft tissues, thus allowing to diversify illnesses treatable by this method, by going to replace the portion of damaged tissue/organ with a scaffold of identical origin to the portion to be regenerated but with the previously described regenerative characteristics.